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Review details mechanisms, clinical uses and limits of tACS across neuropsychiatric disorders

A review led by Prof. Hongxing Wang (Chinese Medical Journal, 5 Apr 2026) summarizes proposed mechanisms and reported clinical uses of tACS across depression, Alzheimer's, schizophrenia and stroke, and calls for larger randomized trials and closed-loop protocols.

23 Apr 2026

A “muddy intervention”: taVNS yields mixed outcomes for people with Long COVID

People with Long COVID are trying ear-based vagus nerve stimulation at home with mixed outcomes. Small trials, a 2024 survey and ongoing studies show both benefit for some users and reports of crashes and adverse effects; experts advise caution and physician oversight.

23 Apr 2026

Nature Reviews Bioengineering publishes framework for digital biomarkers in neurodegenerative disease

A Stanford-led review published 23 April 2026 in Nature Reviews Bioengineering presents a three‑pillar framework for digital biomarkers in neurodegenerative disease, highlights mature motor measures (like gait via IMUs) and lists gaps: small studies, interoperability, equity and cost-effectiveness.

23 Apr 2026

Chaotic heartbeat patterns track cognitive brain activity better than conventional HRV, Kyoto researchers report

Kyoto University researchers found that chaos-based measures of heart-rate variability change with cognitive task load while conventional HRV does not, suggesting a noninvasive signal of brain–heart coupling (Scientific Reports, 2026).

23 Apr 2026

Medtronic launches Adaptive Deep Brain Stimulation system in India

Medtronic has introduced its Adaptive Deep Brain Stimulation (aDBS) system in India, using US FDA‑approved BrainSense sensing to adjust stimulation in real time for Parkinson’s patients. The company says the device aims to improve symptom control and extend battery life amid a rising Parkinson’s burden in India.

23 Apr 2026

SCRATCH‑HTN pilot: ear‑based neuromodulation safe but misses primary endpoint; 12 mmHg signal in highest‑BP subgroup

At ACC 2026, investigators reported SCRATCH‑HTN pilot results: transcutaneous autonomic neuromodulation was safe and acceptable but did not beat sham overall; a subgroup with higher baseline systolic blood pressure showed about a 12 mmHg reduction. The randomized pilot enrolled 63 patients (2:1 randomization).

22 Apr 2026

Northwestern team prints artificial neurons that activate living mouse brain cells

Northwestern researchers printed flexible electronic neurons from MoS2 and graphene that generated complex spike patterns and activated neurons in mouse cerebellum slices, the team reports in Nature Nanotechnology. The paper frames the result as a step toward direct brain–device communication and more energy-efficient neuromorphic hardware.

22 Apr 2026

Japanese team launches open‑label pilot of Vielight PBM for cognitive impairment in schizophrenia

NCNP Tokyo has started a single‑arm 12‑week pilot trial of combined transcranial and intranasal photobiomodulation using the Vielight Neuro Gamma 4 in people with schizophrenia. The study (jRCTs032240756) will prioritize safety and tolerability and explore effects on cognition (MCCB), MMN and frontal NIRS.

22 Apr 2026

Review: Neuromodulation techniques relieve IBS symptoms, long-term benefit uncertain

A 21 April 2026 Frontiers review by Zhang et al. finds electroacupuncture, sacral nerve stimulation, taVNS and TENS can improve IBS symptoms but notes large patient-to-patient variability and limited long-term data.

22 Apr 2026

Effectiveness of Threshold-Level Vagus Nerve Stimulation in Modulating Psychoemotional States

BrainPatch is proud to announce the publication of a new peer-reviewed clinical study titled “Effectiveness of Threshold-Level Vagus Nerve Stimulation in Modulating Psychoemotional States” in the journal Clinical and Preventive Medicine (2026, Issue 2)

21 Apr 2026

MRI-guided TMS reduces amygdala threat responses and improves PTSD symptoms

A randomized, blinded Emory trial found two weeks of MRI-guided low-frequency TMS reduced right amygdala threat responses and produced clinically meaningful PTSD symptom relief in 74% of treated participants, with benefits lasting at least six months.

21 Apr 2026

Pulsed taVNS elicits pupil dilation only with earlobe sham and short pulses, study finds

A Psychophysiology study (Apr 2026) finds pulsed taVNS produces pupil dilation in intermixed trials only with short (1.0 s) pulses and an earlobe sham; using a scapha sham or timing pulses to exhalation removed the effect, challenging a vagal-afferent mechanism.

21 Apr 2026

Trump signs order to speed review of psychedelics, including ibogaine

President Trump has signed an order to accelerate federal review of psychedelic drugs, including ibogaine, a substance backed by some veterans but linked to dangerous heart risks.

20 Apr 2026

brainjo raises €2M to advance VR adjunct for pediatric ADHD therapy

Regensburg startup brainjo raised €2 million in a seed round led by HTGF to fund clinical trials and regulatory work for a VR-based DiGA aimed at children with ADHD, developed with MEDICE Health Family and targeting approval in 2028.

20 Apr 2026

Tomsk Polytechnic University develops magnetoelectric nanoparticles for non‑invasive brain stimulation

Tomsk Polytechnic University researchers report sub‑30 nm magnetoelectric nanoparticles (manganese ferrite core, barium titanate shell) that, in lab tests, tripled neuronal calcium influx and activated 20% more cells; the team says particles are biocompatible at therapeutic concentrations and that in vivo studies are next.

20 Apr 2026

FDA clears Cala kIQ Plus wearable for Parkinson’s hand tremor

The FDA has cleared Cala Health’s Cala kIQ Plus, a wrist‑worn TAPS neurostimulation device for hand tremor in Parkinson’s and essential tremor; company data from 78 patients will be presented at AAN 2026.

19 Apr 2026
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